The two saints —Andrew, from the earliest years of Christianity and Francis, from the thirteenth century— engage in a lively conversation. Their depiction together may be due to a specific devotion.

Saint Andrew's large cross is the compositional and color-based nexus that links the two saints, who are very elongated and are seen from a very low viewpoint.

The work is signed in Greek letters in the lower right corner, on the cartouche.

This work comes from the Convent of la Encarnación in Madrid.