Palomino, who had personal contact with this brother of the well-known painter, José Antolínez, described him as "fastidious and extravagant." Francisco's professional activity as a lawyer did not hinder his curiosity about innumerable subjects, including everything related to intellectual erudition. These interests led him to painting, at which he was successful with small works that generally depict tiny figures in a landscape or among buildings. Although painting was his major source of income, he did not sign his works, as he preferred to present himself as a lawyer. Consequently, his only known signed painting is an Adoration of the Shepherds (Seville Cathedral) that established the criteria for attributing other similar works to him—mostly small and particularly decorative pieces from religious series marked by a particular exploration of light effects rendered in a fast and agitated manner. The Museo del Prado has eight canvases attributed to Francísco Antolínez, all from the Museo de la Trinidad.