Christ is presented as the Savior of the World, blessing humankind, between Saint John and the Virgin, who turn towards him. The three figures are shown three-quarters under arches with a complex gothic tracery. In the center is a circular skylight with a singing angel leaning out.

This is a free copy of the same figures in the polyptych of the Mystic Lamb by Jan and Hubert van Eyck from the Cathedral of Saint Bavon in Ghent. With his eloquent expression, Saint John is the figure that most differs from the original model.

The complex architecture makes it possible to date this work in the decade of 1510, following the painter's return from Rome.

It belonged to Felipe II, who sent it to El Escorial in 1584.