A New Testament scene (Luke 1, 26-38) that depicts the Archangel Gabriel's Annunciation to the Virgin Mary and her acceptance of the fact that she will become the Mother of God through the intercession of the Holy Ghost. The Virgin is accompanied by three of her traditional attributes: a sewing basket and book, which symbolize her hard work and devotion; and a spray of lilies, which symbolize her purity.

This devotional painting belonged to a type of straightforward and very tender works that were very successful in Sevillian society following the plague epidemic of 1649.

This canvas was acquired in Seville in 1729-33 by Queen Isabel de Farnesio and is listed in the 1746 inventory of the La Granja Palace and the 1749 inventory of the Aranjuez Palace, both in Madrid.