The Virgin Mary holds the Christ Child in her arms in front of a green curtain, accompanied by Saint Dorothy and Saint George in a Sacra Conversazione.

Saint George (fourth century) wears armor and carries his symbol, the lance with which, according to legend, he slew the dragon. Saint Dorothy (fourth century) was originally from Cappadocia and suffered Emperor Diocletian's persecution of Christians. Here, she presents a basket of flowers to the Christ Child, an allusion to her final miracle when, just moments before she was martyred, she miraculously made a basket of fruit and flowers appear in front of one of her executioners, who had made fun of her.

In this work, Titian displays his mastery of technique with a clear exposition and brilliant colors that contrast with his early work under Giorgione.

A copy of this painting, with small variations, is at Hampton Court, London.

This is the earliest painting by Titian owned by Felipe II (1556-1589), who sent it to El Escorial in 1593. It entered the Prado Museum in 1839.