The upper part of the drawing depicts Christ with the lightning bolt of the plague in the right hand, surrounded by angels, with more darts and flaming swords. The Virgin raises her hands in supplication, and a group of angels shows the Cross and the Attributes of the Passion. In the lower part, Saint Charles Borromeo kneeling with the Holy Nail in the right hand, is surrounded by the corpses and the dying. In the background, the city walls of Milan can be observed.

It is a preliminary work, with notable differences, for the painting of the Minor Clerics of Salamanca, now held at the Nueva Catedral (New Cathedral) of this city. Another drawing for the same composition is kept in the National Library. This one in the Museo del Prado, of somewhat inferior quality but faithful in details, could be nothing more than a contemporary imitation, produced in Camilo’s workshop.

Museo Nacional del Prado, Catálogo de dibujos T. I. Dibujos españoles, siglos XV-XVII / por A. E. Pérez Sánchez, Madrid, Museo Nacional del Prado, 1972, p.46