This is part of a fresco originally in the church of San Giacomo degli Spagnoli in Rome, from where it was removed from the wall just before 1907, the year it entered the Prado with an attribution to Baldassare Peruzzi. It is in fact by Antoniazzo Romano, a painter greatly in demand from the Spanish community in Rome due to his skillful fusion of Renaissance pictorial innovations with the devotional power of icons.